Radiation Enteritis Medical Advisory Board for Soligenix, Inc

Lisa Kachnic, MD

Chairperson, Department of Radiation Oncology
Boston University Medical Center

Dr. Kachnic is Chairperson of the Department of Radiation Oncology at Boston University Medical Center and serves on the Radiation Oncology faculty at the Massachusetts General Hospital. She also serves as GI Radiation Oncology Chair and Discipline Vice-chair of the Radiation Oncology Committee for the Southwest Oncology Group. As such, she has served as principal or co-principal investigator on several national trials, a Phase 2 trial evaluating dose-painted Intensity Modulated Radiation Therapy (IMRT) in combination with 5-fluorouracil and mitomycin-C for the reduction of acute morbidity in carcinoma of the anal canal. As a tribute to these efforts, Dr. Kachnic has been awarded funding as Principal Investigator, National Cancer Institute, U10 CA37422, "Community Clinical Oncology Program (CCOP) Radiation Therapy Oncology Group," and is the 2008 recipient of the first Radiation Therapy Oncology Group (RTOG) "Next Generation Investigator" Award. Dr. Kachnic belongs to a number of professional organizations including the American Society for Therapeutic Radiation and Oncology (ASTRO), American Society of Clinical Oncology (ASCO), American Association for Cancer Research (AACR), Radiation Research and the International Society of Gastrointestinal Oncology. She serves on the editorial boards of the Journal of the National Cancer Institute and Gastrointestinal Cancer Research, and contributes her radiation expertise to the National Cancer Institute's Adult Oncology Treatment Editorial Board and to the U.S. Department of Defense Medical Research Study Sections. She is actively involved in the Radiation Therapy Oncology Group's GI and Outcome strategic committees and has been the RTOG Chairperson of Symptom Management since 2003. Dr. Kachnic received her undergraduate degree from Boston College and her medical degree from Tufts University. She completed her residency in Radiation Oncology at Harvard University, with her last year as chief resident.

George B. McDonald, MD

Professor of Medicine, University of Washington School of Medicine and Head, Gastroenterology/Hepatology Section Fred Hutchinson Cancer Research Center

Dr. McDonald is a Professor of Medicine at the University of Washington School of Medicine and a Member at the Fred Hutchinson Cancer Research Center, where he is head of the Gastroenterology/Hepatology Section. He also serves as the head of the Program in Complications of Cancer Treatment that has as its goals the reduction of morbidity from cancer treatment, improved survival, and prevention of late sequelae of cancer treatment. Dr. McDonald's research is focused on gastrointestinal and hepatobiliary complications of hematopoietic cell transplantation, specifically problems involving the toxicity of high-dose myeloablative regimens that are used to prepare patients for transplantation and acute and chronic Graft-versus-Host Disease involving the gastrointestinal tract and liver. He has recently developed and validated a new method of assessing the severity of acute GVHD, called the acute GVHD Activity Index, an accurate predictor of transplant-related mortality. He was the lead investigator on the clinical trials that pioneered the use of topical corticosteroid therapy with oral beclomethasone dipropionate for GI GVHD.

Marvin Rotman, MD

Professor and Chairman, Department of Radiation Oncology
SUNY Downstate Medical Center

Dr. Rotman is the Professor and Chairman of the Department of Radiation Oncology at SUNY Downstate Medical Center in Brooklyn, NY and a leader in developing cancer treatments that combine continuous infusion chemotherapy and radiation therapy. Dr. Rotman has held senior offices and board positions at major professional societies in his field and has been active in the RTOG and numerous other medical research projects. He has held high office locally (New York Roentgen Society, Radiotherapy Section Chairman, and President, New York Cancer Society) and nationally (President of The American Radium Society, Executive Committee Member-At-Large of ASTRO, Second Vice President of the Radiological Society of North America, and President of the Society of Chairmen of Academic Radiation Oncology Departments) and has served on the Radiation Oncology Residency Review Committee. He is the co-author of four textbooks and the author or co-author of over 40 medical textbook chapters. He has more than 150 refereed journal publications to his credit. Prior to his appointment to the chair at SUNY Downstate, Dr. Rotman was professor of radiology at New York Medical College. Dr. Rotman received his medical degree from Jefferson Medical College and trained at Albert Einstein Medical Center in Philadelphia and at Montefiore Medical Center in the Bronx. He also did post-graduate training at the M.D. Anderson Hospital and Tumor Institute in Houston.

William Small, Jr. MD, FACRO

Professor of Radiation Oncology
Northwestern University Medical School

Dr. Small is the Professor of Radiation Oncology and Vice-President of the Department of Radiation Oncology at Northwestern University Medical School in Chicago, IL, as well as an Attending Physician at the Northwestern Memorial Hospital. He is a member of various medical societies, including, but not limited to, the American Association of Cancer Researchers, the American College of Radiation Oncology, the American College of Radiology, and the American Medical Association. Dr. Small is a recipient of numerous awards. For the past four years, he has been honored as one of the "Best Doctors in America." He was included in the "Guide to Top Radiologists 2007," "Outstanding Physicians – Chicago Consumers' Checkbook," and "America's Top Doctors for Cancer." Dr. Small has authored or co-authored 60 journal articles, eight book chapters, two books, and over 45 scientific abstracts. He is on the editorial boards of Cancer News and The American Journal of Radiation Oncology, and is a reviewer for over 15 medical journals such as The American Journal of Clinical Oncology, The British Journal of Cancer, and JAMA. Dr. Small earned his medical degree from the Northwestern University Medical School. He held an internship in internal medicine at the Northwestern Memorial Hospital where he also completed a residency in radiation oncology.