While in all cases of radiation damage, the initial damage is caused by cell death, often subsequent damage is caused by the repair processes of the body which are driven by inflammation and may be “over driven” by these inflammatory processes. As the hematopoietic system recovers, this “overdrive” scenario may become worse.
OrbeShield® is a topical anti-inflammatory treatment for the stomach and intestines which may help address deleterious inflammation in the gastrointestinal system. The active ingredient is beclomethasone dipropionate (BDP).
BDP is a steroid which can reduce local inflammation but has limited ability to penetrate the body.
By providing a formulation of BDP which coats the inside of the gut with steroid, but isn’t absorbed into the bloodstream, the systemic side effects of steroid treatment (including increased risk of infection) are reduced.
OrbeShield® may mitigate the “inflammatory overdrive” occurring in GI ARS, allowing the recovering intestinal cells to structure themselves correctly while reducing long term side effects.