Acute Radiation Syndrome Scientific Advisory Board - Scientific Advisors

George E. Georges, MD

Associate Professor of Medicine at the University of Washington
Member, Fred Hutchinson Cancer Research Center

Dr. Georges is an Associate Professor of Medicine at the University of Washington and Associate Member, Fred Hutchinson Cancer Research Center, is recognized internationally as an expert in ARS, with a specific focus on bone marrow and GI components. Dr. Georges’ research focus is on development of radiation counter-measures in the dog model with the goal of translating the findings to the clinical care of patients. He is the Principal Investigator of several NIH sponsored grants including development of radiation mitigators for acute radiation syndrome associated neutropenia and thrombocytopenia, as well as the gastrointestinal syndrome. This research includes canine studies with new cytokines for improving hematopoietic recovery and immune reconstitution after radiation. In addition, he has developed the canine model of GI-ARS to study novel agents to mitigate the effects of radiation injury in the gut. He has more than 70 peer-reviewed publications.

Thomas MacVittie, MS, PhD

Professor of Radiation Oncology and Pathology at the University of Maryland School of Medicine

Dr. MacVittie is a Professor of Radiation Oncology and Pathology at the University of Maryland School of Medicine and is recognized internationally as an expert on the effects of radiation on the hematopoietic and gastrointestinal systems in non-human primates and their treatment. His early work demonstrated the efficacy of medical management (supportive care) and hematopoietic growth factors on increasing survival in lethally irradiated large animal models. The MacVittie group’s database demonstrating the effect of cytokines on enhancing survival and recovery of hematopoiesis serves as the focal point for current efforts to design the first pivotal trials under the FDA’s animal rule to determine the treatment efficacy of candidate drugs/biologics for final FDA approval. Dr. MacVittie has served as an advisor to the World Health Organization (WHO) Collaborating Centers in Radiation Emergency Medical Preparedness and Assistance and the International Council on Radiation Protection and as a member of North Atlantic Treaty Organization (NATO) Radiation Research Study Groups. He is a member of the Centers for Disease Control and Prevention (CDC) Strategic National Stockpile Radiation Working Group, the International Association of Radiopathology, the American Society of Hematology, the International Society of Experimental Hematology, Radiation Research and the International Society of Cellular Therapy. Dr. MacVittie is a member of the editorial board of the journal Stem Cells and serves as an ad hoc reviewer for numerous journals and NIH/National Institute of Allergy and Infectious Diseases (NIAID) and Department of Defense (DoD) grants and contracts. He was also a consultant for the International Atomic Energy Agency (IAEA) and Canadian Defense Research Establishment and also served on the first National Biodefense Science Board Federal Advisory Committee at the invitation of the Secretary, U.S. Department of Health and Human Services. He has more than 150 peer-reviewed publications.

George B. McDonald, MD

Professor of Medicine, University of Washington School of Medicine and Member, Gastroenterology/Hepatology Section, Fred Hutchinson Cancer Research Center

Dr. McDonald is a Professor of Medicine at the University of Washington School of Medicine and a Member at the Fred Hutchinson Cancer Research Center, in the Gastroenterology/Hepatology Section. His overall research goals have been the reduction of morbidity from cancer treatment, improved survival, and prevention of late sequelae of cancer treatment. Dr. McDonald is recognized internationally as an expert in the field of gastroenterology. His research is focused on gastrointestinal and hepatobiliary complications of hematopoietic cell transplantation, specifically problems involving the toxicity of high-dose radiation/chemotherapy regimens that are used to prepare patients for transplantation and acute and chronic Graft-versus-Host disease (GVHD) involving the gastrointestinal tract and liver. He has recently developed and validated a new method of assessing the severity of acute GVHD, called the acute GVHD Activity Index, an accurate predictor of transplant-related mortality. He was the lead investigator on the clinical trials that pioneered the use of topical corticosteroid therapy with oral beclomethasone dipropionate for GI GVHD. He is also collaborating with Dr. George Georges on evaluating the effects of radiation injury on the GI tract in the canine model of GI-ARS. He has more than 200 peer-reviewed publications.

George A. Parker, DVM, PhD

Vice President, Pathology at WIL Research

Dr. Parker is currently Vice President, Pathology at WIL Research. Dr. Parker is a graduate of Auburn University College of Veterinary Medicine. He completed a residency program in veterinary pathology at the Armed Forces Institute of Pathology and a PhD program in molecular and cellular immunology at the University of Medicine and Dentistry of New Jersey. He is certified as a pathologist by the American College of Veterinary Pathology, as a toxicologist by the American Board of Toxicology, and is a Fellow of the International Academy of Toxicologic Pathologists. He has been continuously involved in toxicologic pathology since 1978. Dr. Parker has served as study pathologist on over 1000 good laboratory practice (GLP) and non-GLP toxicology studies, and has served as primary reviewer for more than 1400 GLP pathology reports. He currently directs a pathology department that includes 13 pathologists and approximately 70 technical or clerical staff members. He has more than 60 peer-reviewed publications.

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