SGX201 is designed as a topical treatment for the gut. The active ingredient is beclomethasone 17,21-dipropionate (BDP).
BDP is a steroid which can reduce local inflammation but has limited ability to penetrate the body.
By providing a formulation of BDP which coats the inside of the gut with steroid, but isn’t absorbed into the bloodstream, the systemic side effects of steroid treatment are reduced.
SGX201 may be a safe alternative for prevention of acute and chronic radiation enteritis.
How is SGX201 Delivered?
SGX201 is an oral, enterically coated pill containing the active ingredient BDP. The pill is designed to dissolve in the intestine, coating the bottom half of the gastrointestinal tract and providing direct anti-inflammatory action.
What is Known About BDP?
Beclomethasone dipropionate (BDP) is a very well-known steroid that has been used in inhaled products for asthma, in nasal sprays for rhinitis and in skin creams for rashes. It has been used in children and adults for over 40 years. There is a lot of information known about the safety and efficacy of BDP.
Mechanism of Action
As with all corticosteroids, BDP binds to the corticosteroid receptor and has anti-inflammatory action, suppressing the infiltration of inflammatory cells to the local site of action.
The distinguishing feature of BDP is that it does not travel throughout the body easily, meaning that it has a local action without inducing as many side effects throughout the body. This also means that the BDP must be delivered directly to where it is needed – which is reflected in the unique oral formulation that is used in SGX201.
More details on the mechanism of action of SGX201 (BDP) can be found in our Reference Literature.